新型冠状病毒肺炎(COVID-19)是由新型冠状病毒SARS-CoV-2引起的疾病, 在全球范围内大面积传播, 严重威胁公众的健康。研究发现: COVID-19易感人群与缺锌人群存在显著的重合性; 从机制上, 微量元素锌具有抗病毒、调节免疫、抗炎等生理功能, 存在潜在的预防或治疗COVID-19的作用。临床试验结果证实: 单独使用锌补充剂对COVID-19的治疗可能无效, 但锌结合羟氯喹(HCQ)、阿奇霉素(AZM)的三联疗法对COVID-19的早期治疗是有效的。值得尝试开展锌与其他COVID-19治疗试剂的联合给药治疗的临床研究。进一步开展锌盐阻断多蛋白加工和抑制病毒复制活性的试验研究, 可为阐明锌盐在对抗COVID-19中的潜在作用提供机制参考。
Corona virus disease 2019 (COVID-19) is a disease caused by the new coronavirus SARS-CoV-2, which spreads widely around the world and seriously threatens public health. There is a significant overlap between the susceptible population of COVID-19 and the zinc-deficient population. In terms of mechanism, the trace element zinc has physiological functions such as antiviral, immune regulation, and anti-inflammatory, and has a potential role in preventing or treating COVID-19. The clinical trial results confirm that zinc supplementation alone may be ineffective for the treatment of COVID-19, but the triple therapy of zinc combined with hydroxychloroquine (HCQ) and azithromycin (AZM) is effective for the early treatment of COVID-19. It is worth trying to carry out a clinical study on the combined administration of zinc and other COVID-19 therapeutic agents. Further experimental studies on the activity of zinc salts to block polyprotein processing and inhibit viral replication can provide a mechanism reference for elucidating the potential role of zinc salts in combating COVID-19.
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